Chris Langer / msnbc.com
Jennifer and Jason Schiraldi, of Campbell, Ohio, struggled for two years to have a child, without success. A ground-breaking technique at Cleveland Clinic, however, led to the birth of their daughter, Kenley, 9 months.
Everyone knows it takes just one sperm and one egg to make a baby, but nature usually provides extra, just to be sure.
In the case of 9-month-old Kenley Schiraldi of Campbell, Ohio, however, there was no back-up for the biology, requiring instead what scientists -- and her parents -- are calling a modern-day miracle.
Kenley was born last April, the result of a long-shot infertility treatment, a case Cleveland Clinic IVF experts say is the first time a single sperm has been frozen, injected into a single egg -- and resulted in a healthy pregnancy.
“It was better than hitting the lottery,” said Jennifer Schiraldi, 33, Kenley’s mom. “This never happens.”
Indeed, even Nina Desai, director of the IVF laboratory at the Cleveland Clinic, hasn’t calculated the odds of Kenley’s conception, which occurred even though her father, Jason, produced no sperm in the regular way, and her mom had trouble producing eggs.
“It was like a shot in the dark,” said Desai, who has developed a ground-breaking technique that can find and store tiny amounts of sperm -- or even just one -- in a drop of fluid inside a straw as thin as a sewing needle. The sperm can then be frozen and later thawed for use in an in-vitro fertilization technique known as intracytoplasmic sperm injection, or ICSI.
The new method follows nearly two decades of efforts to save the smallest possible amounts of human sperm by storing the cells inside hamster eggs or on tiny nylon loops for easier retrieval later. It’s expected to be a boon for men with very low sperm counts, a severe form of the male factor infertility that can contribute to the 1 in 8 couples in the U.S. who struggle to conceive.
Jennifer Schiraldi, a hospital dietician, and her husband, Jason, 35, a cardiac catheterization nurse, came to the Cleveland Clinic in 2009, after trying for two years to get pregnant, with no success. High school sweethearts who’ve been married nine years, they were young and healthy with no warning that they’d have trouble having a baby.
“I’d never had any woman problems and you never think it’s the guy,” recalled Jennifer.
In fact, however, tests showed that the Schiraldis were among 30 percent to 40 percent of infertile couples with problems attributed to the man.
“They took a sample and we found out immediately: There’s no sperm,” Jennifer Schiraldi recalls.
The couple could have stopped there, but they decided to pursue aggressive infertility treatment, including a testicular biopsy, which involves surgery to remove tiny bits of tissue to test for evidence of sperm.
The procedure was difficult, admits Jason Schiraldi, but he said he was determined to try everything.
“We always wanted kids and I didn’t want to be the one who couldn’t do that for her,” he said.
But searching for Jason’s sperm proved even harder than imagined. As the surgeon sent down samples, Desai’s lab staffers, three in all, used microscopes to scan the tissue for any sign of viable cells.
A typical male produces 60 million to 100 million lively sperm in a single ejaculation.
After searching Jason’s tissue for a total of nine hours, the scientists found -- one.
“We froze that one sperm and we saved the rest of the specimens,” recalled Desai. “We really had no hope of it doing anything.”
Because any pregnancy with so few sperm would require in-vitro fertilization, Jennifer Schiraldi had to harvest her eggs. But when they went to retrieve them, doctors found she made far fewer eggs than normal.
“I got 12 but only eight were good,” she recalled.
IVF experts searched the rest of Jason’s samples, hoping to fertilize as many of Jennifer’s eggs as possible. When they found only a couple dead sperm, the one frozen viable sperm was the only option.
“They got the one sperm and implanted the one egg,” Jennifer Schiraldi said.
Desai admits she wasn’t optimistic.
“People don’t usually get pregnant when they have only one egg,” she explained, noting that it’s far more common to implant two or three embryos to make sure pregnancy occurs.
But then came the exciting part. With the help of a careful ICSI procedure, the egg was successfully fertilized. Three days later, it had divided into a viable embryo and was implanted in Jennifer’s womb.
Sixteen days after that, she was confirmed pregnant.
“It was very emotional,” said Jason Schiraldi.
Back at the clinic, the staff shared congratulations.
“I was really surprised when I saw she had a positive pregnancy,” said Desai. "This has been one of the real miracles in our IVF program."
The pregnancy was normal but taxing, with a fair amount of nausea and other ordinary complications, Jennifer Schiraldi said. And the baby was in the breech position, which required a C-section.
But when Kenley Karlin Schiraldi arrived on April 20, her parents said there was no doubt about what had occurred.
“Miracle is not a large enough word to describe it,” said Jason Schiraldi. “Of all the fascinating and amazing things we do in the health care field, it’s amazing that this happened to us.”
Jennifer Schiraldi says she looks at her daughter every day and marvels that she’s here.
“It’s crazy. Sometimes I’m, like, ‘Did we cheat?’” she said. “People ask if we’re going to have another child, but we made it this far to get her. I don’t know if I even want to press my luck.”
Desai and her colleagues plan to use the new sperm storage technique to help other patients with very low sperm counts. Next week, in fact, another man with the same problem is scheduled for the treatment.
Jason Schiraldi said other couples should be encouraged by their experience.
“People think once you’re stuck, you’re stuck,” he said. “But there are people who can make wonderful things happen.”
Discuss this story on our TODAY Health Facebook page.
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How wonderful this is for the entire family! I congratulate them on their double miracle--the IVF and the healthy baby. Life is a miracle.
And this is good news????? Slightly obsessive for sure... As for "winning the lottery,"..... more like Reverse Lottery: no doubt that the entire procedure and birth cost in the six-figures and now the Narcissistic couple faces $260K (on average) to raise the pup.
Bob, hmmmm....that's a little cynical, don't ya think?..........no--wait....change that! THAT'S EXTREMELY CYNICAL!!.......hope yer not a parent...
Bob you are indeed a troll. It is good that you will probably not reproduce. There are already to many trolls around.
WOW!! You mean the sperm did what it was inhierently designed to do?! AMAZING!! Next week, "Woman gets only 1 egg fetilized."
I get the feeling that this may have been like the lotto. The normal egg gets countless "suitors", where this one was like a shot in the dark. I'll have to give this one to the doctors.....
NO.
The sperm did not do what it was inherently designed to do.
It was not designed to be frozen or 'inserted'.
It evolved to compete with millions of other sperm and work it's own way into the egg- under it's own power- ahead of the others- thusly assuring that the strongest sperm survive by producing a healthy live born child..
I rejoice for this family who is happy with the process and certainly wish the beautiful child a long and happy life.
Just answering the question.
Congratulations to the family! A child is a wonderful thing, no matter what it takes to get them. I give them a lot of credit to go through all that, I would have just given up and adopted.
Congrats to them... however this doesn't sound like a "miracle" to me... just the "evil work" of that pesky "made-up science stuff." ;-)
Life is never "evil".....maybe, the taking of life, but not life itself. I think this is a case where God has probably enlightened science in that such a marvelous thing is possible.
This story makes me cry. I know the hearbreak of infertility. My husband and I tried for 9 long years to conceive. We finally found out we also had male factor infertility. Our only choice was IVF with ICSI. This proceedure is very costly, so we had only one chance to try it. We were blessed with our miracles, boy/girl twins, in 2010. I am so very happy for this family.
Glad you are happy... but why not adopt?
Obviously, you don't understand the joy that comes from "pro-generating" your own genes. Still, adoption is a good thing too!
Why is this a miracle??? The whole story tells how this was SCIENTIFICALLY done!! Just because it doesn't always work, doesn't change the fact that it could/should.
Yeah. If a sperm and an egg that are pushed together can't make a baby, then it wasn't meant to be. But then I also feel that nature's design shouldn't be messed with too much. We're overpopulated already. Do we really need to force babies where they aren't viable? No, adoption's not the same as having your own but there are plenty of kids out there who are already alive who need parents more than a sperm and egg cell that can't figure out how to reach each other without scientific interference.
As someone who has gone through fertility treatments - mine were cheaper ($12,ooo) than adoption was going to be ($40,000) and we had a baby within a year. You won't find that with infant adoptions anywhere. My husband and I would have adopted, but we didn't want to use all our life savings to do so when we still would need money to raise a child.
Me and my husband only have one child and we consider him to be our miracle, being that we have never used anything and been with each other over 12 years. We ave in the past year just got coustody of another agel and we are so blessed. They are truly blessed as well with a gift from above. I am excited for them and suck it all in because gosh they grow so fast.
Congrats to that family!
Someday I hope we have a master race of clones and get rid of the lesser speicies.
Well, I think this is a WONDERFUL story! If I couldn't have kids, I would have gone to any length to have them also. Any amount of money they had to spend is worth that precious little girl they now have. And they have also given hope to many other couples with the same problem. I have thought about being a surrogate mother and this makes me consider it again.
No need to go to lengths. Just go to your neighborhood adoption agency. There are plenty of children there who need parents, who don't require lengthy medical procedures or "miracles" to make them. They're packed and ready to go today.
Actually, they're not 'packed and ready to go'. Adoption requires lots of background checks, medical checks, classes, etc. It's not like you go there, pick out a kid, and go home with the kid within a week.
Whew! With the shortage of kids and all , this is a huge relief. (_!_)'s.
you sure know your emoticons...
Her look like her Daddy. I gonna squeez her cheeks, hug her, pat her, kiss her. . . . Makes me feel so happy to look at this picture. Congratulations and God bless you. XOXO
?!!
Perhaps if they want more children they can adopt next time. It would be nice to share the joy with a child that needs a family.
My thoughts exactly. While this little girl is certainly a wonderful miracle, I think I would have turned to adoption rather than this extensive (and I'm sure expensive) process.
So, the little girl is part hamster? If so, I've got a barely used 'hamster wheel' in my yard-sale bin, if needed.
yeah, you gotta love that part. Now was the hamster already dead, did they kill the rodent for this, or was the hamster a live incubator?
Its a miracle because it takes millions of sperm to get one to fertilize an egg. They used a single sperm and it worked, do you negative nancys know what the odds are on that happening.
Hate to break it to you but it only takes 1 sperm to fertilize an egg. You can't use more than one. Once one has reached the nucleus of the egg, the outer portion of the egg hardens, locking all others out. The reason men normally shoot millions is to increase the chances of one of them being strong enough and smart enough to get all the way there.
When you push a sperm into an egg, you take away all the travel time and guesswork. If a baby can't be made this way, it wasn't meant to be. There's no miracle here, anymore than it would be a miracle to get chocolate milk after you add a tablespoon of chocolate to a glass of milk. What would be shocking is if you *didn't* get chocolate milk after stirring.
I went to the Cleveland Clinic Fertility Doctors to conceive#2. What they went through is horrendous (and I did not do IVF). The pain of infertility is heartwrenching. They did get a miracle. Every child is a miracle. This a million times over.
Going to that much trouble to have a biological child is the ultimate conceit particularly in a world where so many children need families, they just don't happen to be perfect white infants.
I'd like to know what would have happened if their child had been less than perfect...
. . .and yes, this is miracle. A totally unneccessary miracle based, like ALL miracles, in reality (in this case science), and not mumbo jumbo.
Happens all the time ! Usually in the back seat of a teenagers car !
Wow....lots of "Debbie-Downers" out there! Just a little science for you - in the average couple with zero infertility issues, there is only a 20% chance each month of conception. And, on average, it take a couple 4-5 months to conceive, even when actively trying. Just because an egg and sperm are introduced does NOT guarantee conception by any stretch of the imagination. To say that this was a 'Miracle' is quite a stretch (hence, the reason the author uses quotations for that word), but it is a very neat scientific feat. All in all, I think it should just be accepted for what it is - a feel-good story about a couple who wanted to have a baby and were able, even if it was with a little help from modern science.
And, Jersey Bob - I didn't hear that they were using your money for this whole event, including raising their child? So, stop complaining and go back to chasing kids off your lawn.
Congrats on the child. Your hard work paid off. To all of you young girls out there this is proof that it only takes one swimmer to get by and your a mommy forever.
I have another take on this - why were the sperm and egg counts so low?
Campbell OH is near Youngstown, OH, both southeast of Cleveland OH. Generally between Cleveland OH and Pittsburgh PA. As a former resident of that general area, it is my understanding that there is a higher than normal rate of cancer in that region. For many years, Cleveland, Detroit, Pittsburgh, Buffalo, NY and places in between were home to many heavy industries that put quite a bit of pollution into the environment. I'm wondering if there is an environmental cause to the low sperm and egg counts in these two people. Anyone know more on this?
Of course, I will be attacked by the right wing, "we have the God given right to pollute", "do you want jobs or clean environmnet" element out there. Gee, did they ever think there may be consequenses to pollution?
True- since they were high school sweethearts, it's quite likely that they (and possibly their parents) grew up in the same area, and could have been exposed to the same localized pollutants.
I feel uneasy about this. A baby is a wonderful thing, but, that child only inherited seriously bad reproductive genes and there is a huge possibility she wont be able to have children either. Plus, I'm not very religious, but, I think playing God is wrong. This is no better than Cloning..I read an article the other day about how a lady paid 50K to clone her DOG, wow, nutcase. Anyways, If they were meant to have kids, they would've been able to have kids, and instead of being selfish and spending the probable six figures a new procedure like this would cost, just go adopt a baby. There are millions that need adopting. My father was adopted, there's nothing wrong with adoption. Sheesh
What a nice story to read! Congrats to all... My husband and I tried for over 2 years with no luck. turned out to be him, A little surgery. (verioclies ) and we now have two healty children.